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infection biology

Year
27 March 2024

Using Data Hubs to analyse SARS-CoV-2 and other pathogen sequences

The SARS-CoV-2 Data Hubs are a set of tools coupled with infrastructure that support four components: the submission, analysis, presentation and visualisation of SARS-CoV-2 raw read data, and its resulting analyses. What makes Data Hubs attractive is a unique set of features: A new publication in…

2024

updates-from-data-resources

21 December 2023 On the left: image of a protein complex in a shape of a yellow doughnut with blue elements. Above it is a drawing of nucleic acid with arrows connecting nitrogenous bases to different points in the protein complex. On the right: a line with peaks indicating the peaks recorded in mass spectrometry. Above two peaks, there are smaller depictions of the doughnut-shaped complex, one with a blue element and one without.

RNA to rule them all

Science & Technology The Kosinski Group at EMBL Hamburg collaborated with other groups in Hamburg to reveal critical steps in Lassa virus ribonucleoparticle assembly and recruitment, and the crucial role played by RNA in in the Lassa virus life cycle.

2023

sciencescience-technology

26 October 2023 Photographs of three scientists on a decorative blue background

EMBL scientists receive prestigious ERC Synergy Grants

EMBL Announcements Jan Kosinski, Julia Mahamid, and Georg Zeller have received grants to enable ambitious projects aimed at mapping the cellular protein synthesis machinery in context and understanding complex host-microbiome interactions, respectively.

2023

embl-announcementsscience

10 July 2023 Green parasites on black background

Spotlight: Shedding light on deadly parasites

Lab MattersScience & Technology This single-celled organism the size of a dust particle is capable of causing deadly tropical diseases in both humans and livestock –Trypanosoma brucei, in an image by Luciano Dolce from EMBL.

2023

lab-matterspicture-of-the-weekscience-technology

7 July 2023 Cartoon of a molecule, formed by sticks and spheres.

Facilitating drug discovery against COVID-19

Science & Technology A collaboration between EMBL Grenoble and EBRIS scientists led to the characterisation of a new compound with promising activity against SARS-CoV-2 variants.

2023

sciencescience-technology

20 December 2022

First linked dataset on Pathogens Portal

The first  cohort study linking data across categories was recently added on the Pathogens Portal Cohort Browser and is also accessible from the BioSamples browser. This pilot study comes from Erasmus Medical Centre through the ReCoDID project, one of the COVID-19 Data Platform supporting…

2022

updates-from-data-resources

1 December 2022

Getting closer to stopping toxoplasmosis infection

Science & Technology Recent studies supported by EMBL Grenoble’s expertise in structural biology research and scientific services have identified Altiratinib as a potential drug to stop toxoplasmosis infection and opened up treatment options against malaria.

2022

sciencescience-technology

1 August 2022

Shining a light on how bacteria interact

Science & Technology Machine learning has helped researchers uncover new insights into how bacteria infect host cells.

2022

research-highlightssciencescience-technology

7 June 2022 Female scientist photographed in a garden

Welcome: Pascale Cossart

Lab MattersPeople & Perspectives Pascale Cossart, one of the world’s foremost authorities on the biology of Listeria, brings four decades of expertise in intracellular bacterial parasitism to EMBL as a visiting scientist.

2022

lab-matterspeople-perspectives

30 March 2022 Man standing in front of a wall with scientific imagery including protein structures

Welcome: John Lees

Lab MattersPeople & Perspectives John Lees joins EMBL-EBI as a Group Leader in Pathogen informatics and modelling.

2022

lab-matterspeople-perspectives

4 March 2022 Colourful shapes are set against a black background and white grid, symbolic of aspects of infection biology.

A postdoc conference spotlighted in tweets

Lab Matters EMBL hosted a futuristic infection biology conference, but it offered even more: an opportunity for postdocs to share their work and network towards future research homes.

2022

eventslab-matters

22 December 2021 Scientific illustrations of MEG3, a very large RNA involved in cell proliferation. IAB and EMBL logos are located in the center of the illustration.

EMBL-IAB collaboration on the rise

ConnectionsLab Matters The memorandum of understanding (MoU) signed between EMBL and the Institute for Advanced Biosciences (IAB) a year ago has already catalysed new grants for joint research projects related to cancer and infection biology, thereby deepening collaborative activities.

2021

connectionslab-matters

20 December 2021 A detailed structure map shows two proteins interacting in the foreground, each shown in a different colour. The background shows small green dots marking bacteria

Solving molecular puzzles to find the perfect fit

Science & Technology Using cryo-EM and structural biology techniques, EMBL researchers have shown how two proteins of Legionella pneumophila interact. This finding sheds light on a mechanism critical to the infection process and could lead to the development of new drugs to treat pneumonia.

2021

sciencescience-technology

15 October 2021 In the middle, there are two molecules of pUL21. One is blurred, to represent the molecule’s flexibility. In the background are two neuronal scenes. The one on the left is healthy and has a smooth surface. The one on the right is infected, which is represented by several green viral particles.

How herpes seizes proteins’ means of production

Science & Technology The Graham and Crump groups at the University of Cambridge and the Svergun Group at EMBL Hamburg have discovered a mechanism by which the herpes simplex virus takes control of the molecular machinery of human cells. Their work reveals how a dedicated viral protein hijacks key host proteins, forcing…

2021

sciencescience-technology

7 October 2021 SARS-CoV-2 and planet Earth are merged together in this illustration

Six Ways to Protect the Planet Against Pandemics*

Science & Technology EMBL will host a conference to look at the state of the pandemic, lessons learned, and ways to improve pandemic preparedness. Here’s a sneak peek into what promises to be another interesting and informative EMBL conference.

2021

eventsscience-technology

22 September 2021 Logos of EMBL and Helmholtz Association on white background, over a green-and-blue pattern in the background.

EMBL and Helmholtz Health join forces

ConnectionsLab Matters EMBL and Helmholtz Association have signed a memorandum of understanding. The expanded collaboration of both institutions will focus on research related to health.

2021

connectionslab-matters

25 May 2021 Microscope image of an engineered human blood vessel, featuring individual cells outlined in pink with blue nuclei.

Barriers against malaria

Science & Technology The Bernabeu Group aims to increase our knowledge of cerebral malaria, using in vitro engineered networks of human blood vessels and brain cells.

2021

picture-of-the-weekscience-technology

21 May 2021 Image of a mosquito on a clear surface

EMBL scientists support malaria research

Science & Technology EMBL scientists support research on malaria by providing freely available data resources and using innovative experimental approaches. Our Course and Conference Office facilitates the exchange of knowledge in the field by hosting the annual BioMalPar conference.

2021

sciencescience-technology

2 December 2020 Curly-shaped trypanosomes, grey with bright specks of green fluorescent protein, against a grey background.

Tackling tropical diseases

Science & Technology Members of the EMBL community are working to improve our understanding of the parasites that cause malaria and sleeping sickness

2020

sciencescience-technology

10 November 2020 Green coloured brain cells next to a microfluidic network.

Understanding malaria

Science & Technology To help understand cerebral malaria the Bernabeu group has created in vitro engineered networks of human blood vessels.

2020

picture-of-the-weekscience-technology

13 October 2020 Molecular structure of essential light chain protein in Plasmodium glideosome. The atoms connected by bonds are symbolised by short connected lines. They are surrounded by electrons – the electron density is depicted as shapes resembling clouds. Water molecules are visible in several places as red spots. The data used to create this 3D model were obtained using X-ray crystallography at Petra III beamline, at EMBL Hamburg.

How deadly parasites ‘glide’ into human cells

Science & Technology A group of scientists led by EMBL Hamburg’s Christian Löw provide insights into the molecular structure of proteins involved in the gliding movements through which the parasites causing malaria and toxoplasmosis invade human cells.

2020

sciencescience-technology

8 July 2020 Artwort illustrating various aspects of infection research. The centre of the image shows a cartoon representation of a coronavirus. The spheric shape has been overlaid with a map of the world to illustrate the global spread of viruses. The edges of the artwork feature images of potential virus hosts (bats, poultry, dromedary), a group of humans, a microscope, pills, a syringe and vaccine vial, protein structures, and an illustration of a human lung. The background is set in yellow and red colour.

What COVID-19 is teaching us

Science & Technology The virtual EMBL Conference ‘SARS-CoV-2: Towards a New Era in Infection Research’ explored the importance of fundamental research, collaboration, and data science in containing the SARS-CoV-2 pandemic, and discussed opportunities to improve our response to pandemics in the future.

2020

eventsscience-technology

17 June 2020 Crystal selection for X-ray diffraction experiments.

Investigating the structure and mechanisms of coronavirus biomolecules

Science & Technology While global research on coronaviruses has shed light on the function of many SARS-CoV-2 proteins, the role of some crucial components remains unknown. Researchers at EMBL Grenoble will use a range of structural biology methods to try to solve some of the puzzles of the molecular mechanics of…

2020

sciencescience-technology

15 June 2020 Key visual for the virtual EMBL conference ‘SARS-CoV-2: Towards a New Era in Infection Research’. Credits: Aleksandra Krolik/EMBL

Improving our response to emerging pandemics

EMBL Announcements The emergence of previously unknown pathogens, such as the novel coronavirus SARS-CoV-2, raises many questions. To explore these questions in an international scientific forum, EMBL will host the virtual conference ‘SARS-CoV-2: Towards a New Era in Infection Research’ on 3 July. Invited…

2020

embl-announcementsevents

27 May 2020 Automated sample changer and diffractometer at the ID30B X-ray crystallography beamline at ESRF Grenoble.

Facilitating COVID-19 structural biology research

Connections EMBL and the European Synchrotron Radiation Facility (ESRF) restart the activities of the Joint Structural Biology Group in Grenoble to support coronavirus-related projects. A new initiative will allow users to be granted access to the High-Throughput Crystallisation (HTX) lab at EMBL and to a…

2020

connectionsscience

5 May 2020 Liquid handling robot transfering protein crystalisation solutions

Responding to health threats posed by coronaviruses

Science & Technology By re-opening the High-Throughput Crystallisation (HTX) lab at EMBL Grenoble, EMBL is supporting structural biology projects to respond to the health threats posed by coronaviruses.

2020

sciencescience-technology

29 April 2020 The Influenza virus

Understanding the influenza virus

Science & Technology The infectious disease commonly known as flu is caused by the influenza virus. It spreads around the world in seasonal outbreaks, causing millions of infections and hundreds of thousands of deaths each year. Stephen Cusack, Head of EMBL Grenoble, has been studying different aspects of the influenza…

2020

sciencescience-technology

28 April 2020 Close-up view of the interior of a protein analytics system

Exploring synthetic antibodies to stop coronavirus

Science & Technology Scientists at EMBL Hamburg and Karolinska Institutet Stockholm aim to find synthetic antibodies – known as nanobodies – that bind a surface protein of the novel SARS-CoV-2 coronavirus. Nanobodies could prevent the virus from entering human cells and causing COVID-19.

2020

sciencescience-technology

3 March 2016 Colorised scanning electron micrograph of red blood cell infected with malaria parasites (blue); uninfected cells with a smooth red surface. IMAGE: (CC BY 2.0)

Mapping malaria

Science & Technology First detailed atlas of start points for genes expression in malaria-causing parasite

2016

sciencescience-technology

1 October 2009 These microscopy images show that, in A. gambiae mosquitoes, the different alleles of the TEP1 gene confer different degrees of resistance to malaria: the midgut of a mosquito whose only functional allele is the 'resistance' one (left) contains a number of dead malaria parasites (black dots), but very few live parasites (fluorescent green dots), whereas in another, genetically identical, mosquito with only the 'susceptibility' allele turned on (right), parasite survival was much higher. Image credit: Marina Lamacchia/INSERM

From foe to friend: mosquitoes that transmit malaria may help fight the disease

Science & Technology For many years, the mosquitoes that transmit malaria to humans were seen as public enemies, and campaigns to eradicate the disease focused on eliminating the mosquitoes. But, as a study published today in Science shows, the mosquitoes can also be our allies in the fight against this common foe,…

2009

sciencescience-technology

5 April 2006

With joint forces against Malaria

Connections Today the network of excellence for Biology and Pathology of the Malaria Parasite (BioMalPar), will bring together the world’s elite in the field of Malaria research at the European Molecular Biology Laboratory (EMBL) in Heidelberg. At the second annual BioMalPar conference, organised jointly…

2006

connectionsevents

21 December 2005

A key that opens cells to the deadly malaria parasite

Science & Technology Researchers at the International Centre for Genetic Engineering and Biotechnology (ICGEB) in India and a unit of the European Molecular Biology Laboratory (EMBL) in France have made a key discovery about a molecule that helps the malaria parasite infect human cells. India is one of the countries…

2005

sciencescience-technology

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