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infectious disease

Year
27 March 2024

Using Data Hubs to analyse SARS-CoV-2 and other pathogen sequences

The SARS-CoV-2 Data Hubs are a set of tools coupled with infrastructure that support four components: the submission, analysis, presentation and visualisation of SARS-CoV-2 raw read data, and its resulting analyses. What makes Data Hubs attractive is a unique set of features: A new publication in…

2024

updates-from-data-resources

21 December 2023 On the left: image of a protein complex in a shape of a yellow doughnut with blue elements. Above it is a drawing of nucleic acid with arrows connecting nitrogenous bases to different points in the protein complex. On the right: a line with peaks indicating the peaks recorded in mass spectrometry. Above two peaks, there are smaller depictions of the doughnut-shaped complex, one with a blue element and one without.

RNA to rule them all

Science & Technology The Kosinski Group at EMBL Hamburg collaborated with other groups in Hamburg to reveal critical steps in Lassa virus ribonucleoparticle assembly and recruitment, and the crucial role played by RNA in in the Lassa virus life cycle.

2023

sciencescience-technology

20 December 2022

First linked dataset on Pathogens Portal

The first  cohort study linking data across categories was recently added on the Pathogens Portal Cohort Browser and is also accessible from the BioSamples browser. This pilot study comes from Erasmus Medical Centre through the ReCoDID project, one of the COVID-19 Data Platform supporting…

2022

updates-from-data-resources

15 October 2021 In the middle, there are two molecules of pUL21. One is blurred, to represent the molecule’s flexibility. In the background are two neuronal scenes. The one on the left is healthy and has a smooth surface. The one on the right is infected, which is represented by several green viral particles.

How herpes seizes proteins’ means of production

Science & Technology The Graham and Crump groups at the University of Cambridge and the Svergun Group at EMBL Hamburg have discovered a mechanism by which the herpes simplex virus takes control of the molecular machinery of human cells. Their work reveals how a dedicated viral protein hijacks key host proteins, forcing…

2021

sciencescience-technology

25 May 2021 Microscope image of an engineered human blood vessel, featuring individual cells outlined in pink with blue nuclei.

Barriers against malaria

Science & Technology The Bernabeu Group aims to increase our knowledge of cerebral malaria, using in vitro engineered networks of human blood vessels and brain cells.

2021

picture-of-the-weekscience-technology

21 May 2021 Image of a mosquito on a clear surface

EMBL scientists support malaria research

Science & Technology EMBL scientists support research on malaria by providing freely available data resources and using innovative experimental approaches. Our Course and Conference Office facilitates the exchange of knowledge in the field by hosting the annual BioMalPar conference.

2021

sciencescience-technology

17 February 2021 Illustration of a pink capsule passing through a grey pore in a yellow membrane.

A new piece of the HIV infection puzzle explored

Science & Technology Researchers from EMBL and Heidelberg University Hospital combine high-resolution imaging to observe the infection process in cell nuclei, opening the door for new therapeutics.

2021

sciencescience-technology

2 December 2020 Curly-shaped trypanosomes, grey with bright specks of green fluorescent protein, against a grey background.

Tackling tropical diseases

Science & Technology Members of the EMBL community are working to improve our understanding of the parasites that cause malaria and sleeping sickness

2020

sciencescience-technology

10 November 2020 Green coloured brain cells next to a microfluidic network.

Understanding malaria

Science & Technology To help understand cerebral malaria the Bernabeu group has created in vitro engineered networks of human blood vessels.

2020

picture-of-the-weekscience-technology

13 October 2020 Molecular structure of essential light chain protein in Plasmodium glideosome. The atoms connected by bonds are symbolised by short connected lines. They are surrounded by electrons – the electron density is depicted as shapes resembling clouds. Water molecules are visible in several places as red spots. The data used to create this 3D model were obtained using X-ray crystallography at Petra III beamline, at EMBL Hamburg.

How deadly parasites ‘glide’ into human cells

Science & Technology A group of scientists led by EMBL Hamburg’s Christian Löw provide insights into the molecular structure of proteins involved in the gliding movements through which the parasites causing malaria and toxoplasmosis invade human cells.

2020

sciencescience-technology

8 June 2020 Microscopic image showing a macrophage that has been infected with Salmonella (green), causing cellular cathepsins (red) to locate to the nucels (blue).

Re-trafficking proteins to fight Salmonella infections

Science & Technology Scientists including members of EMBL’s Typas group have investigated how immune cells called macrophages respond to infection by the intracellular pathogen Salmonella enterica. They discovered that Salmonella causes newly produced cathepsins to accumulate in the nuclei of infected cells to…

2020

sciencescience-technology

28 April 2020 Close-up view of the interior of a protein analytics system

Exploring synthetic antibodies to stop coronavirus

Science & Technology Scientists at EMBL Hamburg and Karolinska Institutet Stockholm aim to find synthetic antibodies – known as nanobodies – that bind a surface protein of the novel SARS-CoV-2 coronavirus. Nanobodies could prevent the virus from entering human cells and causing COVID-19.

2020

sciencescience-technology

24 April 2020 Collage of images representing wet and dry lab research and healthcare

Why share data during a pandemic?

Science & Technology In March 2020, planes were grounded, streets went quiet, and our lives changed forever. But while the world came to a halt, many scientists were ramping up their efforts to understand the new virus.

2020

sciencescience-technology

20 April 2020 COVID-19 Data Portal logo on globe background

EMBL-EBI launches COVID-19 Data Portal

Science & Technology The new collaborative space will help scientists, public health and healthcare professionals around the world to fight the coronavirus pandemic.

2020

sciencescience-technology

26 September 2019 The Old Port of Marseille.

EMBL and Tara: Marseille

EMBL Announcements From 27–30 September, Tara will be docked in the port of Marseille, France’s second largest city.

2019

embl-announcementsevents

3 March 2016 Colorised scanning electron micrograph of red blood cell infected with malaria parasites (blue); uninfected cells with a smooth red surface. IMAGE: (CC BY 2.0)

Mapping malaria

Science & Technology First detailed atlas of start points for genes expression in malaria-causing parasite

2016

sciencescience-technology

1 October 2009 These microscopy images show that, in A. gambiae mosquitoes, the different alleles of the TEP1 gene confer different degrees of resistance to malaria: the midgut of a mosquito whose only functional allele is the 'resistance' one (left) contains a number of dead malaria parasites (black dots), but very few live parasites (fluorescent green dots), whereas in another, genetically identical, mosquito with only the 'susceptibility' allele turned on (right), parasite survival was much higher. Image credit: Marina Lamacchia/INSERM

From foe to friend: mosquitoes that transmit malaria may help fight the disease

Science & Technology For many years, the mosquitoes that transmit malaria to humans were seen as public enemies, and campaigns to eradicate the disease focused on eliminating the mosquitoes. But, as a study published today in Science shows, the mosquitoes can also be our allies in the fight against this common foe,…

2009

sciencescience-technology

4 May 2008

Getting wise to the influenza virus’ tricks

Science & Technology Influenza is currently a grave concern for governments and health organisations around the world. Now one of the tactics used by influenza virus to take over the machinery of infected cells has been laid bare by structural biologists at the EMBL, the joint Unit of Virus Host-Cell Interaction of…

2008

sciencescience-technology

22 June 2007

New compound effectively treats fungal infections

Science & Technology A new mechanism to attack hard-to-treat fungal infections has been revealed by scientists from the biotech company Anacor Pharmaceuticals Inc., California, and the European Molecular Biology Laboratory [EMBL] outstation in Grenoble, France. In the current issue of Science they describe…

2007

sciencescience-technology

25 February 2007

A first glimpse of the influenza replication machine

Science & Technology In 1918, 50 million people died during a worldwide influenza pandemic caused by mutation of a bird-specific strain of the influenza virus. Recently H5N1, another highly infectious avian strain has caused outbreaks of bird flu around the world. There is great concern that this virus might also…

2007

sciencescience-technology

12 February 2007

A signal that protects the liver from hepatitis and cancer

Science & Technology Liver cancer is one of the deadliest cancers worldwide; every year sees more than 400,000 new cases, and most of the victims die in less than one year. Despite extensive research, the underlying molecular mechanisms of the disease are poorly understood. A new study by researchers from the Mouse…

2007

sciencescience-technology

5 April 2006

With joint forces against Malaria

Connections Today the network of excellence for Biology and Pathology of the Malaria Parasite (BioMalPar), will bring together the world’s elite in the field of Malaria research at the European Molecular Biology Laboratory (EMBL) in Heidelberg. At the second annual BioMalPar conference, organised jointly…

2006

connectionsevents

21 December 2005

A key that opens cells to the deadly malaria parasite

Science & Technology Researchers at the International Centre for Genetic Engineering and Biotechnology (ICGEB) in India and a unit of the European Molecular Biology Laboratory (EMBL) in France have made a key discovery about a molecule that helps the malaria parasite infect human cells. India is one of the countries…

2005

sciencescience-technology

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