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korbel

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28 May 2024 An illustration of cells in a mosaic context, demonstrating the idea of genetic mosaicism in blood stem cells.

Genetic mosaicism more common than thought

Science & Technology Blood stem cells from healthy people carry major chromosomal alterations, a study in Nature Genetics by researchers at the Max Delbrück Center and the European Molecular Biology Laboratory (EMBL) finds. The discovery suggests that we are all genetic mosaics, which may contribute to ageing-related…

2024

science-technology

22 March 2023 Artistic representation that features a long, winding helix joining together a doughnut-figure to a small shaggy ball to indicate the connections long-read sequencing can make about DNA mutations.

The ‘long read’ for cancer

Using Oxford Nanopore long-read sequencing, EMBL scientists sequenced a primary childhood brain tumour known as a medulloblastoma, uncovering a novel complex mutation pattern.

2023

science

6 May 2022 Drawing of two chromosomes in which a highlighted area is switched around.

Flip-flop genome

Science & Technology Researchers at EMBL Heidelberg found that inversions in the human genome are more common than previously thought, which impacts our understanding of certain genetic diseases.

2022

sciencescience-technology

16 July 2020 A collage of portrait photos of Jessica Vamathevan, Jan Korbel, and Nassos Typas.

Changes in senior roles at EMBL

EMBL AnnouncementsLab Matters Three changes in senior staff positions have been confirmed at EMBL today. Jessica Vamathevan becomes Head of Strategy, Jan Korbel becomes Head of Data Science for EMBL Heidelberg, and Nassos Typas becomes Senior Scientist.

2020

embl-announcementslab-matters

30 June 2020

EMBL boosts national and international sharing of genomic data

ConnectionsLab Matters A national consortium including EMBL and the DKFZ is set to launch the German Human Genome–Phenome Archive, creating an invaluable bridge between fundamental biomedical research and applied healthcare.

2020

connectionslab-matters

13 May 2020 Close-up photograph of servers at EMBL Heidelberg's data centre.

Understanding the role of our genes in SARS-CoV-2 infections

Science & Technology EMBL scientists will contribute to the new German COVID-19 OMICS Initiative to study the biological mechanisms contributing to coronavirus infections. EMBL group leaders Jan Korbel and Oliver Stegle, who is also affiliated with the DKFZ Heidelberg, will coordinate the set-up of IT infrastructures…

2020

sciencescience-technology

1 April 2020

Understanding brain tumours in children

Science & Technology The causes of 40 percent of all cases of certain medulloblastoma – dangerous brain tumours affecting children – are hereditary. These are the findings of a recent genetic analysis carried out by scientists from EMBL and numerous colleagues around the world.

2020

sciencescience-technology

5 February 2020

The Pan-Cancer project

Science & Technology EMBL co-leads most comprehensive study of genetic causes of cancer

2020

sciencescience-technology

5 February 2020

Analysis of human genomes in the cloud

Science & Technology Scientists from EMBL present a tool for large-scale analysis of genomic data with cloud computing. Main advantages of the new tool, called Butler, are continuous system monitoring and its ability to self-heal in case of failure, allowing for 43% more efficient data processing than previous…

2020

sciencescience-technology

5 February 2020

Finding genetic cancer risks

Science & Technology Using the data from the Pan-Cancer project EMBL scientists describe how our genetic background influences cancer development.

2020

sciencescience-technology

15 July 2019 The pyramids represent chromatin domains in the wild-type situation. The reflection in the water below represents the rearrangements in the mutant fruit fly chromosomes. At first glance the (regulatory) landscapes look very similar, but there are lots of changes to the topology, and yet these have little impact on the nature of the landscape (gene expression). IMAGE: Beata Edyta Mierzwa in collaboration with EMBL.

Rearranging chromosomes

Science & Technology Does rearranging chromosomes affect their function? EMBL scientists reveal uncoupling of 3D chromatin organisation and gene expression.

2019

sciencescience-technology

10 December 2018 artistic impression of the double helix structure of DNA

Model to predict prostate cancer progress

Science & Technology Cancer researchers have developed a computer model to predict the course of disease for prostate cancer

2018

sciencescience-technology

23 May 2018 As a cell prepares to divide, the chromosomes (shown here in pink) condense, becoming more tightly coiled and easier to observe under the microscope. The faint structure in the centre is a cell nucleus in which the chromosomes are in their usual decondensed state.

Exploring genetic variation

Science & Technology EMBL group leader Jan Korbel reflects on his scientific origins and current research

2018

sciencescience-technology

29 August 2016

Awards & Honours

EMBL AnnouncementsLab Matters EMBL scientists regularly receive prestigious awards – meet the latest honourees.

2016

embl-announcementslab-matters

24 November 2015

Awards & Honours

EMBL AnnouncementsLab Matters EMBL scientists regularly receive prestigious awards – meet the latest honourees.

2015

embl-announcementslab-matters

9 July 2015

The genome in the cloud

Science & Technology Jan Korbel and colleagues publish commentary on risks and rewards of genome cloud computing.

2015

sciencescience-technology

25 June 2014

Taken out of context

Science & Technology Enabling neighbours: intact genes can cause cancer when placed near "enhancing" regions of DNA

2014

sciencescience-technology

2 February 2011

The human genome’s breaking points

A detailed analysis of data from 185 human genomes sequenced in the course of the 1000 Genomes Project, by scientists at the European Molecular Biology Laboratory (EMBL) in Heidelberg, Germany, in collaboration with researchers at the Wellcome Trust Sanger Institute in Cambridge, UK, as well as the…

2011

science

27 October 2010

1000 Genomes Project ushers in new era for human genetics

The 1000 Genomes Project, a major international collaboration to build a detailed map of human genetic variation, has completed its pilot phase. The results are now published in the journal Nature and freely available through the European Molecular Biology Laboratory’s European Bioinformatics…

2010

science

18 March 2010

What makes us unique? Not only our genes

Once the human genome was sequenced in 2001, the hunt was on for the genes that make each of us unique. But scientists at the European Molecular Biology Laboratory (EMBL) in Heidelberg, Germany, and Yale and Stanford Universities in the USA, have found that we differ from each other mainly because…

2010

science

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