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kosinski

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21 December 2023 On the left: image of a protein complex in a shape of a yellow doughnut with blue elements. Above it is a drawing of nucleic acid with arrows connecting nitrogenous bases to different points in the protein complex. On the right: a line with peaks indicating the peaks recorded in mass spectrometry. Above two peaks, there are smaller depictions of the doughnut-shaped complex, one with a blue element and one without.

RNA to rule them all

Science & Technology The Kosinski Group at EMBL Hamburg collaborated with other groups in Hamburg to reveal critical steps in Lassa virus ribonucleoparticle assembly and recruitment, and the crucial role played by RNA in in the Lassa virus life cycle.

2023

sciencescience-technology

26 October 2023 Photographs of three scientists on a decorative blue background

EMBL scientists receive prestigious ERC Synergy Grants

EMBL Announcements Jan Kosinski, Julia Mahamid, and Georg Zeller have received grants to enable ambitious projects aimed at mapping the cellular protein synthesis machinery in context and understanding complex host-microbiome interactions, respectively.

2023

embl-announcementsscience

10 June 2022 A colourful structural model of the doughnut-shaped human nuclear pore complex seen from above.

Puzzling out the structure of a molecular giant

Science & Technology Scientists have solved several mysteries around the structure and function of a true molecular giant: the human nuclear pore complex. They created the most complete model of the complex thanks to combining the program AlphaFold2 with cryo-electron tomography, integrative modelling, molecular…

2022

sciencescience-technology

21 December 2021 A model of the doughnut-shaped nuclear pore complex. Individual molecules are marked in various colours.

Observing the secret life of molecules inside the cell

Science & Technology EMBL Hamburg’s Kosinski Group, the Beck Laboratory at the Max Planck Institute of Biophysics, and colleagues at EMBL Heidelberg recorded the nuclear pore complex contracting in living cells. They visualised the movement with an unprecedented level of detail with help of new software called…

2021

sciencescience-technology

3 September 2020 Left: Slice of a cell in grey. Right: Two 3D reconstructions of parts of the slice, showing the internal structure.

Nuclear pores in their natural context

Science & Technology Scientists from the Beck group have studied the 3D structure of nuclear pores in budding yeast. They show how the architecture of the nuclear pore complex differs inside cells compared to its form observed in vitro studies.

2020

sciencescience-technology

7 April 2020

Exciting science!

Science & Technology EMBL is all about exciting science, through which we aim to achieve a fundamental understanding of biological processes.

2020

picture-of-the-weekscience-technology

11 July 2019 Structure of the Elongator complex

A tRNA modifier at work

Science & Technology Using cryo-EM, scientists have determined the structure of a large protein complex called Elongator.

2019

sciencescience-technology

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