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Researchers have identified key cellular control sites that regulate gene expression and prevent the activation of ancient viral sequences in the genome.
SCIENCE & TECHNOLOGY2024
science-technology
The GEEF facility at EMBL Rome supports scientists worldwide with scientific expertise and state-of-the-art gene editing technologies.
LAB MATTERSSCIENCE & TECHNOLOGY2022
lab-mattersscience-technology
Researchers have combined spatial gene expression information with single-cell genomics data to create a high-resolution atlas of mouse organogenesis.
SCIENCE & TECHNOLOGY2021
sciencescience-technology
Scientists at EMBL Heidelberg have investigated stem cells and how they differentiate to become neurons. Their approach included an assessment of the complex interplay of molecules during the differentiation process and generated fundamental new insights into the role of a protein called Sox2 in…
SCIENCE & TECHNOLOGY2020
sciencescience-technology
To study how SARS-CoV-2 infects cells, the Gene Editing and Embryology Facility (GEEF) at EMBL Rome will generate mice that express a human version of a protein called ACE2. The mouse line will be shared with preclinical research collaborators carrying out vaccine and antibody trials, and with the…
SCIENCE & TECHNOLOGY2020
sciencescience-technology
Researchers from the Sharpe group at EMBL Barcelona have published a method to track the developmental history of a cell using the gene editing tool CRISPR–Cas9, but without the need to create transgenic organisms.
SCIENCE & TECHNOLOGY2020
sciencescience-technology
The brain is the most complex organ in the human body. Yet despite it being the organ that makes us conscious beings – and despite the fact that researchers have been studying it for generations – it’s still a constant source of surprise. To help lift the veil on some of its mystery, Lina…
SCIENCE & TECHNOLOGY2019
picture-of-the-weekscience-technology
Nadia Rosenthal describes how she built EMBL Rome’s mouse house
PEOPLE & PERSPECTIVES2019
alumnipeople-perspectives
Klaus Rajewsky recalls the pioneering spirit of EMBL Rome’s first years
PEOPLE & PERSPECTIVES2019
alumnipeople-perspectives
Nobel prize laureate Susumu Tonegawa describes his work in memory research over the past decade
LAB MATTERS2019
eventslab-matters
Scientists at EMBL Rome develop new method that uses light to manage neuropathic pain in mice
SCIENCE & TECHNOLOGY2018
sciencescience-technology
In many people with autism and other neurodevelopmental disorders, different parts of the brain don’t talk to each other very well. Scientists have now identified, for the first time, a way in which this decreased functional connectivity can come about. In a study published online today…
SCIENCE & TECHNOLOGY2014
sciencescience-technology
What do bullies and sex have in common? Based on work by scientists at the European Molecular Biology Laboratory (EMBL) in Monterotondo, Italy, it seems that the same part of the brain reacts to both. In a study published today in Nature Neuroscience, the researchers found that – at least in…
SCIENCE & TECHNOLOGY2013
sciencescience-technology
During embryo development, genes are dynamically, and very precisely, switched on and off to confer different properties to different cells and build a well-proportioned and healthy animal. Fgf8 is one of the key genes in this process, controlling in particular the growth of the limbs and…
SCIENCE & TECHNOLOGY2013
sciencescience-technology
As spring arrives, flowers seem to bloom everywhere – even under the microscopes at the European Molecular Biology Laboratory (EMBL) in Heidelberg, Germany. But the ‘flowers’ in this picture actually help an animal, not a plant, to pass on its genes. The image, which has been false-coloured…
SCIENCE & TECHNOLOGY2012
picture-of-the-weekscience-technology
Scientists at the European Molecular Biology Laboratory (EMBL) in Heidelberg, Germany, have developed a new method for studying gene regulation, by employing a jumping gene as an informant. Published online today in Nature Genetics, the new method is called GROMIT. It enables researchers to…
SCIENCE & TECHNOLOGY2011
sciencescience-technology
Fear can make you run, it can make you fight, and it can glue you to the spot. Scientists at the European Molecular Biology Laboratory (EMBL) in Monterotondo, Italy and GlaxoSmithKline in Verona, Italy, have identified not only the part of the brain but the specific type of neurons that determine…
SCIENCE & TECHNOLOGY2010
sciencescience-technology
Almost a century after it was discovered in fruit flies with notches in their wings, the Notch signalling pathway may come to play an important role in the recovery from heart attacks. In a study published today in Circulation Research, scientists at the European Molecular Biology Laboratory (EMBL)…
SCIENCE & TECHNOLOGY2009
sciencescience-technology
For scientists at the European Molecular Biology Laboratory (EMBL) in Monterotondo, Italy, what seemed like a disappointing result turned out to be an important discovery. Their findings, published online this week in the journal Proceedings of the National Academy of Sciences (PNAS), provide…
SCIENCE & TECHNOLOGY2009
sciencescience-technology
Stem cells have a unique ability: when they divide, they can either give rise to more stem cells, or to a variety of specialised cell types. In both mice and humans, a layer of cells at the base of the skin contains stem cells that can develop into the specialised cells in the layers above.…
SCIENCE & TECHNOLOGY2009
sciencescience-technology
Mouse mothers-to-be have a remarkable way to protect their unborn pups. Because the smell of a strange male’s urine can cause miscarriage and reactivate the ovulatory cycle, pregnant mice prevent the action of such olfactory stimuli by blocking their smell. Researchers from the European…
SCIENCE & TECHNOLOGY2008
sciencescience-technology
Researchers from the European Molecular Biology Laboratory (EMBL) have discovered that proteins that regulate the body’s iron household play a vital role in making sure enough nutrients and water are absorbed in the intestine. Mice lacking these proteins suffer from weight loss and…
SCIENCE & TECHNOLOGY2008
sciencescience-technology
Researchers from the European Molecular Biology Laboratory (EMBL) and the University of Michigan have discovered a gene that protects us against a serious kidney disease. In the current online issue of Nature Genetics they report that mutations in the gene cause nephronopthisis (NPHP) in humans and…
SCIENCE & TECHNOLOGY2007
sciencescience-technology
Why does the same diet make some of us gain more weight than others? The answer could be a molecule called Bsx, as scientists from the European Molecular Biology Laboratory (EMBL), the German Institute for Nutrition (DIFE), Potsdam, and the University of Cincinnati report in the current issue of…
SCIENCE & TECHNOLOGY2007
sciencescience-technology
People who suffer from anxiety tend to interpret ambiguous situations, situations that could potentially be dangerous but not necessarily so, as threatening. Researchers from the Mouse Biology Unit of the European Molecular Biology Laboratory (EMBL) in Italy have now uncovered the neural basis for…
SCIENCE & TECHNOLOGY2007
sciencescience-technology
Inflammatory bowel diseases, such as Crohn’s disease and Ulcerative Colitis, severely impair the lives of more than four million people worldwide. The development of effective therapies against these diseases requires an understanding of their underlying molecular mechanisms. Researchers from…
SCIENCE & TECHNOLOGY2007
sciencescience-technology
Phone numbers, the way to work, granny’s birthday – our brain with its finite number of nerve cells can store incredible amounts of information. At the bottom of memory lies a complex network of molecules. To understand how this network brings about one of the most remarkable capacities of…
SCIENCE & TECHNOLOGY2007
sciencescience-technology
Muscle wasting can occur at all ages as the result of genetic defects, heart failure, spinal injury or cancer. A therapy to cure the loss of muscle mass and strength, which has a severe impact on patients’ lives, is desperately sought. Blocking a central signal molecule, researchers from the…
SCIENCE & TECHNOLOGY2006
sciencescience-technology
Blood cells have limited lifespans, which means that they must be continually replaced by calling up reserves and turning these into the blood cell types needed by the body. Claus Nerlov and his colleagues at the European Molecular Biology Laboratory (EMBL) unit in Monterotondo, Italy, in…
SCIENCE & TECHNOLOGY2006
sciencescience-technology
Today three research organisations announce the merging of their expertise to fight cardiovascular diseases, which are among the most common health problems and causes of death in the world. The Magdi Yacoub Institute (MYI) at the UK’s Harefield Heart Science Centre, Imperial College London,…
CONNECTIONSLAB MATTERS2006
connectionslab-matters
One of the most basic yet least understood processes in our bodies is how cells crawl along tissues. This behavior is essential to the formation of an embryo and other processes, but it must be tightly controlled. A disturbance can lead to the spread of cancer cells or diseases like Spina…
SCIENCE & TECHNOLOGY2005
sciencescience-technology
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