müller Archives

9 December 2021 Colourful interwoven coils are displayed against a grid of small black and white photographic images.

A gallery of human RNA polymerases

New structural biology research provides fundamental information critical to understanding enzyme mutations connected to rare diseases and cancers.

SCIENCE & TECHNOLOGY

2021

sciencescience-technology

22 July 2021 Protein structural biology

Great expectations – the potential impacts of AlphaFold DB

A discussion of the applications that AlphaFold DB may enable and the possible impact of the resource on science and society.

SCIENCE & TECHNOLOGY

2021

sciencescience-technology

6 July 2021 Photo of a building with blue sky in the background

New life science Imaging Centre preparing for user access

The EMBL Imaging Centre is preparing for external user access, after an on-time and on-budget build and handover to the science team.

CONNECTIONS LAB MATTERS

2021

connectionslab-matters

8 February 2021 Illustration of a laboratory flask to the left of a microscope against an orange/grey background with a zoomed-in cut-out of the microscope view, which is colourful molecules.

Illustration of a laboratory flask to the left of a microscope against an orange/grey background with a zoomed-in cut-out of the microscope view, which is colourful molecules.

A better look at a human RNA polymerase

New EMBL research shows where & to what degree a component of cellular machinery known as RNA Pol III is mutated and becomes problematic.

SCIENCE & TECHNOLOGY

2021

sciencescience-technology

17 April 2020

Supporting international research on the structure of the coronavirus

EMBL Heidelberg reopens the Cryo-Electron Microscopy Service Platform to support coronavirus structural biology research.

CONNECTIONS

2020

connectionsscience

11 July 2019 Structure of the Elongator complex

A tRNA modifier at work

Using cryo-EM, scientists have determined the structure of a large protein complex called Elongator.

SCIENCE & TECHNOLOGY

2019

sciencescience-technology

24 October 2018 Insulin receptor structural biology. IMAGE: Felix Weis and Christoph Müller / EMBL

More effective insulin thanks to first 3D image

New study reveals how to make therapeutic insulins more effective than they currently are

SCIENCE & TECHNOLOGY

2018

sciencescience-technology

17 January 2018 With help from an external transcription factor (lavender, peach, and green), Pol III (grey) and its built-in transcription factor (yellow), create a cage around a cell’s DNA (plum). IMAGE: EMBL/Matthias Vorländer

With help from an external transcription factor (lavender, peach, and green), Pol III (grey) and its built-in transcription factor (yellow), create a cage around a cell’s DNA (plum). IMAGE: EMBL/Matthias Vorländer

Pol III enzyme grips DNA and begins reading fast

EMBL researchers uncover how a key enzyme that helps cells make new proteins starts its work

SCIENCE & TECHNOLOGY

2018

sciencescience-technology

17 November 2016

New insights into RNA Polymerase I

Cryo EM reconstruction of RNA Polymerase I reveals details of how molecule binds and transcribes DNA

SCIENCE & TECHNOLOGY

2016

sciencescience-technology

30 August 2016 Data by Natalia Wesolowska has been visualised in 3D stereoscopic view, as an anaglyph and a 3D lenticular poster by Stefan Günther & Gustavo de Medeiros at EMBL

Data by Natalia Wesolowska has been visualised in 3D stereoscopic view, as an anaglyph and a 3D lenticular poster by Stefan Günther & Gustavo de Medeiros at EMBL

See data in a new light

3D printing, gaming, virtual reality and lenticular posters bring new perspectives to research

SCIENCE & TECHNOLOGY

2016

sciencescience-technology

2 May 2010 These microscopy images show the region of the embryo larva that will develop into the adult fruit fly’s wing. In cells genetically manipulated so that PR-DUB cannot remove the gene-silencing tag (left), a gene which would normally be silenced becomes turned on (red) - a situation which is corrected when PR-DUB’s activity is restored (right). Image credits: J.Mueller/EMBL.

These microscopy images show the region of the embryo larva that will develop into the adult fruit fly’s wing. In cells genetically manipulated so that PR-DUB cannot remove the gene-silencing tag (left), a gene which would normally be silenced becomes turned on (red) - a situation which is corrected when PR-DUB’s activity is restored (right). Image credits: J.Mueller/EMBL.

Tags on, tags off

During embryonic development, proteins called Polycomb group complexes turn genes off when and where their activity must not be present, preventing specialised tissues and organs from forming in the wrong places. They also play an important role in processes like stem cell differentiation and…

SCIENCE & TECHNOLOGY

2010

sciencescience-technology

28 May 2009

Sugarcoating fruit fly development

Proteins are the executive agents that carry out all processes in a cell. Their activity is controlled and modified with the help of small chemical tags that can be dynamically added to and removed from the protein. 25 years after its first discovery, researchers at the European Molecular Biology…

SCIENCE & TECHNOLOGY

2009

sciencescience-technology

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