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protein structure

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25 June 2024 In the front, a 3D model of three molecules bound together: METTL6 in (orange), serine tRNA synthetase in (shades of lilac) and serine tRNA (black). In the background an illustration of a construction site. Two trucks with ‘UGA’ and ‘AGA’ written on them are visible at the bottom.

An enzyme with a smart friend

Science & Technology EMBL Grenoble’s Kowalinski Group analysed the structure of an enzyme responsible for modifying tRNA molecules to fine-tune protein production. They discovered that to distinguish almost identical, yet different, tRNA molecules, the enzyme uses help from another enzyme – a type of cooperation…

2024

science-technology

19 June 2024 In the centre: green angular origami-like shapes stacked on top of each other. Small orange rectangles akin to adhesive tape are placed where the green shapes connect with each other. In the background: a circle in the middle and cancer cells on the left and right.

‘Invisible’ protein keeps cancer at bay

Science & Technology EMBL Hamburg scientists and collaborators discovered a new molecular mechanism in which an unstructured protein disables one of the main cancer-promoting proteins by gluing them into an elongated stack. Data from human patient samples support the role of this mechanism in prostate cancer…

2024

science-technology

21 December 2023 On the left: image of a protein complex in a shape of a yellow doughnut with blue elements. Above it is a drawing of nucleic acid with arrows connecting nitrogenous bases to different points in the protein complex. On the right: a line with peaks indicating the peaks recorded in mass spectrometry. Above two peaks, there are smaller depictions of the doughnut-shaped complex, one with a blue element and one without.

RNA to rule them all

Science & Technology The Kosinski Group at EMBL Hamburg collaborated with other groups in Hamburg to reveal critical steps in Lassa virus ribonucleoparticle assembly and recruitment, and the crucial role played by RNA in in the Lassa virus life cycle.

2023

sciencescience-technology

15 November 2023 Illustration showing a doorknob with a lock and many protein-marked keys floating towards it.

The secret of molecular promiscuity

EMBLetc Promiscuity is critical for nourishment. How? This question lies at the focus of research by the Löw Group at EMBL Hamburg. Using structural biology methods, they explore how specialised molecules located in the cell membrane allow cells absorb nutrients from their environment.

2023

1 November 2023 Sihyun Sung is standing next to experimental equipment for time-resolved serial X-ray crystallography. The light in the room is pink.

We are EMBL: Sihyun Sung on time-resolved structural biology

Lab MattersPeople & Perspectives In this interview, Sihyun Sung, Postdoctoral Fellow at EMBL Hamburg, talks about making molecular movies with time-resolved serial X-ray crystallography, his sources of inspiration, and the value of forging deeper connections with friends and colleagues.

2023

lab-matterspeople-perspectives

3 July 2023 In the foreground: an intrinsically disordered protein, which has a form of a tangled, unstructured string. In the background: a set of parallel curved lines.

Bringing research on disordered proteins to order

Science & Technology A third of all known proteins are either completely or partially unstructured. EMBL scientists contributed to a new set of guidelines – Minimum Information About a Disorder Experiment (MIADE) – that will help researchers share data on unstructured proteins in a more useful way and will enable…

2023

sciencescience-technology

1 February 2022 A photograph of the Amazonian lancehead snake Bothrops atrox

Decoding the secrets of snake venom

Science & Technology EMBL Hamburg’s Grzegorz Chojnowski from the Wilmanns Group developed software called findMySequence, which identifies proteins’ amino-acid sequences based on electron cryo-microscopy and X-ray crystallography data. It’s useful for identifying unknown proteins in samples from natural sources.

2022

sciencescience-technology

28 January 2022 Collage with protein structure in the background and text in the foreground. Text says "17 organisms on the WHO’s neglected tropical diseases list and 10 organisms on its antimicrobial resistance list"

AlphaFold update – neglected tropical diseases

Latest AlphaFold database update adds 27 new organisms and almost 200,000 new protein structure predictions relevant to neglected tropical diseases and antimicrobial resistance

2022

updates-from-data-resources

15 October 2021 In the middle, there are two molecules of pUL21. One is blurred, to represent the molecule’s flexibility. In the background are two neuronal scenes. The one on the left is healthy and has a smooth surface. The one on the right is infected, which is represented by several green viral particles.

How herpes seizes proteins’ means of production

Science & Technology The Graham and Crump groups at the University of Cambridge and the Svergun Group at EMBL Hamburg have discovered a mechanism by which the herpes simplex virus takes control of the molecular machinery of human cells. Their work reveals how a dedicated viral protein hijacks key host proteins, forcing…

2021

sciencescience-technology

20 April 2021 Black-and-white sphere with coronavirus spike protein structures and a two-layered ring of virus membrane superimposed.

Variations on a spike

Science & Technology What does coronavirus’s spike protein look like in 3D? EMBL scientists and colleagues used cryo-electron tomography and molecular dynamics simulations to find out.

2021

picture-of-the-weekscience-technology

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