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svergun

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29 January 2025 Several curvy strings, representing protein chains, have glowing balls, representing the labels, attached to each other their ends. The distance between the glowing balls is measured by rulers. A ray of light representing X-rays shines at them from the top left.

Several curvy strings, representing protein chains, have glowing balls, representing the labels, attached to each other their ends. The distance between the glowing balls is measured by rulers. A ray of light representing X-rays shines at them from the top left.

Novel analysis of intrinsically disordered proteins

Researchers from Mainz University and EMBL Hamburg have presented a new approach for assessing the form of disordered proteins by using anomalous X-ray scattering method for structural analysis.

SCIENCE & TECHNOLOGY

2025

science-technology

19 December 2023 Cartoon showing nanoparticles on a conveyer belt passing through a machine. They are ordered by size and the smallest one pass through the machine before the bigger ones. A ray of light enters the machine, where a nanoparticle is being scanned, and leaves it on the other side. A monitor on top of the scanning machine shows an X-ray of a nanoparticle.

Cartoon showing nanoparticles on a conveyer belt passing through a machine. They are ordered by size and the smallest one pass through the machine before the bigger ones. A ray of light enters the machine, where a nanoparticle is being scanned, and leaves it on the other side. A monitor on top of the scanning machine shows an X-ray of a nanoparticle.

‘X-ray vision’ for investigation of mRNA nanomedicines

EMBL Hamburg, Johannes Gutenberg University Mainz, Postnova Analytics GmbH, and BioNTech SE have developed a new method to quantitatively investigate sizes of nanoparticles containing mRNA. It may become an important part of regular characterisation of mRNA nanomedicines in the future.

SCIENCE & TECHNOLOGY

2023

sciencescience-technology

2 October 2023 Outline of a human, purple against red background. Red RNA strand in the background, electrocardiogram across the image. On the right, outline of a Nobel prize medal.

Outline of a human, purple against red background. Red RNA strand in the background, electrocardiogram across the image. On the right, outline of a Nobel prize medal.

mRNA nanomedicines scoop Nobel Prize in Physiology or Medicine

Pioneers of the mRNA nanomedicines technology receive 2023 Nobel Prize in Physiology or medicine. EMBL is pleased to have supported the development of the application of the mRNA nanomedicine technology through our long-standing collaboration with BioNTech, Johannes Gutenberg University Mainz and…

SCIENCE & TECHNOLOGY

2023

sciencescience-technology

3 July 2023 In the foreground: an intrinsically disordered protein, which has a form of a tangled, unstructured string. In the background: a set of parallel curved lines.

In the foreground: an intrinsically disordered protein, which has a form of a tangled, unstructured string. In the background: a set of parallel curved lines.

Bringing research on disordered proteins to order

A third of all known proteins are either completely or partially unstructured. EMBL scientists contributed to a new set of guidelines – Minimum Information About a Disorder Experiment (MIADE) – that will help researchers share data on unstructured proteins in a more useful way and will enable…

SCIENCE & TECHNOLOGY

2023

sciencescience-technology

18 May 2022 The visiting group from the Business Academy Aarhus during lunch at the EMBL Hamburg’s terrace

The visiting group from the Business Academy Aarhus during lunch at the EMBL Hamburg’s terrace

EMBL Hamburg is helping train lab techs of the future

Students from the Business Academy Aarhus visit EMBL Hamburg annually. Many of them return later as trainees to gain experience as lab technicians. EMBL Hamburg offers great opportunities to learn diverse techniques and work with various equipment. This experience helps them in their future jobs in…

LAB MATTERS

2022

lab-matters

7 December 2021

A cartoon image showing a person's arm and a needle with a vaccine being injected into it. The text on the left reads: "EMBL research: How structural biologists at EMBL Hamburg help to develop and improve RNA vaccines"

How structural biology helps to make RNA vaccines

RNA vaccines, such as the ones for COVID-19, represent a new approach in vaccine technology. Cy Jeffries, faculty staff scientist at EMBL Hamburg, explains the clever technology behind RNA vaccines, and how structural biology contributes to its development. EMBL Hamburg collaborated on several…

SCIENCE & TECHNOLOGY

2021

sciencescience-technology

8 November 2021 A scientist is carefully handling capilars at the P12 beamline at EMBL Hamburg.

A scientist is carefully handling capilars at the P12 beamline at EMBL Hamburg.

EMBL Hamburg trains future generations of life scientists in using SAXS

Each year, EMBL Hamburg’s Svergun Group offers practical EMBO courses and lecture courses on biological small-angle X-ray scattering (SAXS). The courses provide young scientists an opportunity to gain hands-on experience by measuring their own samples, and by exploring different aspects of SAXS…

LAB MATTERS SCIENCE & TECHNOLOGY

2021

lab-mattersscience-technology

15 October 2021 In the middle, there are two molecules of pUL21. One is blurred, to represent the molecule’s flexibility. In the background are two neuronal scenes. The one on the left is healthy and has a smooth surface. The one on the right is infected, which is represented by several green viral particles.

In the middle, there are two molecules of pUL21. One is blurred, to represent the molecule’s flexibility. In the background are two neuronal scenes. The one on the left is healthy and has a smooth surface. The one on the right is infected, which is represented by several green viral particles.

How herpes seizes proteins’ means of production

The Graham and Crump groups at the University of Cambridge and the Svergun Group at EMBL Hamburg have discovered a mechanism by which the herpes simplex virus takes control of the molecular machinery of human cells. Their work reveals how a dedicated viral protein hijacks key host proteins, forcing…

SCIENCE & TECHNOLOGY

2021

sciencescience-technology

27 July 2021 Dots of various colour arranged in rectangles. Concentric rings of different colour indicate different distances from the centre of the image.

Dots of various colour arranged in rectangles. Concentric rings of different colour indicate different distances from the centre of the image.

Studying coronavirus proteins using small-angle X-ray scattering at European XFEL

A collaboration led by EMBL Hamburg’s Svergun Group used small-angle X-ray scattering (SAXS) at the European XFEL to obtain data on samples containing coronavirus spike proteins and antibodies that bind them.

SCIENCE & TECHNOLOGY

2021

sciencescience-technology

9 July 2021 Melissa Graewert stands in front of steely machine

Melissa Graewert stands in front of steely machine

From antibodies to nanoplastics

EMBL’s Melissa Graewert and colleagues are taking a structural biologist’s approach to better understanding nanoplastic particles.

SCIENCE & TECHNOLOGY

2021

sciencescience-technology

4 June 2021 Man in white shirt and blue jeans standing on a terrace in front of trees, facing the camera.

Man in white shirt and blue jeans standing on a terrace in front of trees, facing the camera.

The power of community

EMBL Director Matthias Hentze describes the Environmental Research Initiative: a community effort to solve global environmental challenges.

LAB MATTERS PEOPLE & PERSPECTIVES

2021

lab-matterspeople-perspectives

9 April 2021 Brightly coloured cartoon coils are set against a multi-coloured backdrop of small circles

Brightly coloured cartoon coils are set against a multi-coloured backdrop of small circles

EMBL Hamburg lights the way to folding next-level origami

Using EMBL Hamburg’s world-class structural biology infrastructure, researchers advance the folding of protein ‘origami’ designed in the lab.

SCIENCE & TECHNOLOGY

2021

sciencescience-technology

1 December 2020 The image shows the beamline P12 at EMBL Hamburg. In the centre, several cylindrical elements are connected into a pipe-like structure. In the front, it is connected to a white box-shaped device, and several smaller devices and cables visible around. There is also a grid visible around the beamline.

The image shows the beamline P12 at EMBL Hamburg. In the centre, several cylindrical elements are connected into a pipe-like structure. In the front, it is connected to a white box-shaped device, and several smaller devices and cables visible around. There is also a grid visible around the beamline.

EMBL facilities support development of RNA vaccines

Biotechnology company BioNTech and Johannes Gutenberg University Mainz conduct collaborative research with EMBL scientists at the beamline P12 in Hamburg

SCIENCE & TECHNOLOGY

2020

sciencescience-technology

29 July 2020 Screenshot from the online SAXS course. Clement Blanchet, a senior scientist in the Svergun group at EMBL Hamburg, is presenting the P12 SAXS beamline at Petra III to the participants.

Screenshot from the online SAXS course. Clement Blanchet, a senior scientist in the Svergun group at EMBL Hamburg, is presenting the P12 SAXS beamline at Petra III to the participants.

EMBL releases online course on solution scattering from biological macromolecules

The Svergun group at EMBL Hamburg has released the course ‘Solution Scattering from Biological Macromolecules’ in an online format for the first time. The course explores different aspects of small-angle X-ray scattering (SAXS) for studying the structure of macromolecules.

EMBL ANNOUNCEMENTS

2020

embl-announcementsevents

9 June 2020 Beamline Hamburg

Beamline Hamburg

Shining high-brilliance beams on coronavirus structure

EMBL researchers are studying COVID-19-related molecules by exposing them to high-brilliance X-ray beams. The Svergun group at EMBL Hamburg is using biological small-angle X-ray scattering (SAXS) as part of a global effort by scientists to elucidate the structural organisation of SARS-CoV-2…

SCIENCE & TECHNOLOGY

2020

sciencescience-technology

13 September 2018 IMAGE: Manon Boschard

IMAGE: Manon Boschard

X-rays reveal surprising shape of scaffolding protein

X-ray experiments show that scaffolding protein PDZK1 has a L-shaped conformation

SCIENCE & TECHNOLOGY

2018

sciencescience-technology

29 May 2018 Intermediate detection in capsid formation of the lumazine synthase enzyme. CREDIT: Aleksandra Krolik / EMBL

Intermediate detection in capsid formation of the lumazine synthase enzyme. CREDIT: Aleksandra Krolik / EMBL

Reconstructing 3D shapes from unmeasurable data

Scientists at EMBL Hamburg determine shapes of intermediate states in dynamic biological systems

SCIENCE & TECHNOLOGY

2018

sciencescience-technology

30 August 2016 IMAGE: EMBL/Spencer Phillips

IMAGE: EMBL/Spencer Phillips

Form follows function

'The PDB plays a crucial role in structural biology research and development'

SCIENCE & TECHNOLOGY

2016

sciencescience-technology

14 September 2015 Erica Valentini. PHOTO: EMBL/Rosemary Wilson

Erica Valentini. PHOTO: EMBL/Rosemary Wilson

From side-project to valuable resource

Introducing the Small Angle Scattering Biological Data Bank, developed at EMBL Hamburg.

LAB MATTERS SCIENCE & TECHNOLOGY

2015

lab-mattersscience-technology

2 July 2015

Building bridges with BioStruct-X

Industrial partners and BioStruct-X facility members gather for Workshop at EMBL Hamburg.

CONNECTIONS

2015

connectionsevents

6 April 2015

Bypassing errors

Coin toss inspires CorMap: a new statistical test that sidesteps need for error estimation.

SCIENCE & TECHNOLOGY

2015

sciencescience-technology

18 November 2014

On a SAXS quest

Course attendees go hunting (protein) aliens in a quest for optimal SAXS data.

2014

events

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