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From snapshots to motion: watching biology in action
With a novel approach, EMBL scientists discovered important interactions between molecular machines, potentially offering new opportunities for drug development.
SCIENCE & TECHNOLOGY2024
science-technology
Understanding genomes, piece by piece
Genomes are made up of thousands of individual pieces – genes – which are expressed at different levels. Researchers at EMBL have shed light on how the placement of a gene affects its expression, as well as that of its neighbours.
SCIENCE & TECHNOLOGY2022
sciencescience-technology
Stronger together
Gene activation requires the cooperative activity of multiple transcription factors. Until now, the mechanism used by these factors to coordinate their actions has been poorly understood. EMBL’s Krebs group presents a DNA footprinting method that makes it possible to determine whether…
SCIENCE & TECHNOLOGY2020
sciencescience-technology
How transcription factors work together
EMBL researchers have developed a method to observe interactions between transcription factors
SCIENCE & TECHNOLOGY2020
sciencescience-technology
A classification tool for transcription factors
The software diffTF quantifies activity of transcription factors and predicts their mode of action
SCIENCE & TECHNOLOGY2019
sciencescience-technology
Understanding a key player in melanoma
A new paper describes a unique mechanism of partner selectivity in transcription factors.
SCIENCE & TECHNOLOGY2019
sciencescience-technology
Transcriptional hubs confer phenotypic robustness
Enhancers in Drosophila embryos gather together to preserve phenotypes under stressful conditions
SCIENCE & TECHNOLOGY2019
sciencescience-technology
Rearranging chromosomes
Does rearranging chromosomes affect their function? EMBL scientists reveal uncoupling of 3D chromatin organisation and gene expression.
SCIENCE & TECHNOLOGY2019
sciencescience-technology
Transcription factors controlled by DNA sequence
EMBL scientists gain mechanistic insights into how cellular signalling controls gene regulation
SCIENCE & TECHNOLOGY2018
sciencescience-technology
DNA replication stress in cancer
Thanos Halazonetis discusses the EMBO/EMBL Symposium: DNA Replication: From Basic Biology to Disease
SCIENCE & TECHNOLOGY2018
eventsscience-technology
Welcome: Wojciech Galej
New group leader Wojciech Galej investigates RNA-protein complexes involved in gene expression
PEOPLE & PERSPECTIVES2017
people-perspectivesscience
Know your cells
How T-cells are trained on what not to kill
SCIENCE & TECHNOLOGY2015
sciencescience-technology
Welcome: Judith Zaugg
Whether it’s information or people, the art of connecting is key to new group leader Judith Zaugg
PEOPLE & PERSPECTIVES2014
people-perspectivesscience
11th EMBL Transcription and Chromatin conference
Experts from multiple fields come together to understand how the instructions in genes are read
SCIENCE & TECHNOLOGY2014
eventsscience-technology
Surprisingly stable long-distance relationships
Surprising finding: enhancers find their targets long before activation in Drosophila embryos
SCIENCE & TECHNOLOGY2014
sciencescience-technology
Chain reactions
Scientists determine the structure of auxin response factors: daisy-chains that regulate gene expression
SCIENCE & TECHNOLOGY2014
sciencescience-technology
Pushing the boundaries of transcription
Like musicians in an orchestra who have the same musical score but start and finish playing at different intervals, cells with the same genes start and finish transcribing them at different points in the genome. For the first time, researchers at EMBL have described the striking diversity of…
SCIENCE & TECHNOLOGY2013
sciencescience-technology
Learning from the linker
Mature cells can be reprogrammed to pluripotency and thus regain the ability to divide and differentiate into specialized cell types. Although these so-called induced pluripotent stem cells (iPS cells) represent a milestone in stem cell research, many of the biochemical processes that underlie…
SCIENCE & TECHNOLOGY2013
sciencescience-technology
New revelations in epigenetic control shed light on breast cancer
Epigenetic regulation – modifications to the structure of chromatin that influence which genes are expressed in a cell – is a key player in embryonic development and cancer formation. Researchers at the European Molecular Biology Laboratory (EMBL) in Heidelberg now gained new insight…
SCIENCE & TECHNOLOGY2008
sciencescience-technology