Science & Technology Genomes are made up of thousands of individual pieces – genes – which are expressed at different levels. Researchers at EMBL have shed light on how the placement of a gene affects its expression, as well as that of its neighbours.
2022
sciencescience-technology
Science & Technology Gene activation requires the cooperative activity of multiple transcription factors. Until now, the mechanism used by these factors to coordinate their actions has been poorly understood. EMBL’s Krebs group presents a DNA footprinting method that makes it possible to determine whether…
2020
sciencescience-technology
Science & Technology EMBL researchers have developed a method to observe interactions between transcription factors
2020
sciencescience-technology
Science & Technology The software diffTF quantifies activity of transcription factors and predicts their mode of action
2019
sciencescience-technology
Science & Technology A new paper describes a unique mechanism of partner selectivity in transcription factors.
2019
sciencescience-technology
Science & Technology Enhancers in Drosophila embryos gather together to preserve phenotypes under stressful conditions
2019
sciencescience-technology
Science & Technology Does rearranging chromosomes affect their function? EMBL scientists reveal uncoupling of 3D chromatin organisation and gene expression.
2019
sciencescience-technology
Science & Technology EMBL scientists gain mechanistic insights into how cellular signalling controls gene regulation
2018
sciencescience-technology
Science & Technology Thanos Halazonetis discusses the EMBO/EMBL Symposium: DNA Replication: From Basic Biology to Disease
2018
eventsscience-technology
People & Perspectives New group leader Wojciech Galej investigates RNA-protein complexes involved in gene expression
2017
people-perspectivesscience
Science & Technology How T-cells are trained on what not to kill
2015
sciencescience-technology
Whether it’s information or people, the art of connecting is key to new group leader Judith Zaugg
2014
science
Experts from multiple fields come together to understand how the instructions in genes are read
2014
events
Science & Technology Surprising finding: enhancers find their targets long before activation in Drosophila embryos
2014
sciencescience-technology
Science & Technology Scientists determine the structure of auxin response factors: daisy-chains that regulate gene expression
2014
sciencescience-technology
Science & Technology Like musicians in an orchestra who have the same musical score but start and finish playing at different intervals, cells with the same genes start and finish transcribing them at different points in the genome. For the first time, researchers at EMBL have described the striking diversity of…
2013
sciencescience-technology
Science & Technology Mature cells can be reprogrammed to pluripotency and thus regain the ability to divide and differentiate into specialized cell types. Although these so-called induced pluripotent stem cells (iPS cells) represent a milestone in stem cell research, many of the biochemical processes that underlie…
2013
sciencescience-technology
Science & Technology Epigenetic regulation – modifications to the structure of chromatin that influence which genes are expressed in a cell – is a key player in embryonic development and cancer formation. Researchers at the European Molecular Biology Laboratory (EMBL) in Heidelberg now gained new insight…
2008
sciencescience-technology
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