x-ray crystallography Archives

27 November 2023 Photo of two people brainstorming at the table covered with several papers and images related to the research project, such as the structure of the molecule, a map with the Solar Lake marked, photo of EMBL Hamburg, photo of Garo Antranikian looking into a microscope, pages of the manuscript, data graphs, and more.

Photo of two people brainstorming at the table covered with several papers and images related to the research project, such as the structure of the molecule, a map with the Solar Lake marked, photo of EMBL Hamburg, photo of Garo Antranikian looking into a microscope, pages of the manuscript, data graphs, and more.

Hamburg collaboration paves the way to cleaner technologies for industry

An interdisciplinary collaboration between Hamburg scientists has yielded new insights into the structure and function of a heat-resistant enzyme from an exotic microbe. In this interview, EMBL Hamburg’s Matthias Wilmanns and TUHH’s Garo Antranikian discuss how their collaboration developed and…

SCIENCE & TECHNOLOGY

2023

sciencescience-technology

1 November 2023 Sihyun Sung is standing next to experimental equipment for time-resolved serial X-ray crystallography. The light in the room is pink.

Sihyun Sung is standing next to experimental equipment for time-resolved serial X-ray crystallography. The light in the room is pink.

We are EMBL: Sihyun Sung on time-resolved structural biology

In this interview, Sihyun Sung, Postdoctoral Fellow at EMBL Hamburg, talks about making molecular movies with time-resolved serial X-ray crystallography, his sources of inspiration, and the value of forging deeper connections with friends and colleagues.

LAB MATTERS PEOPLE & PERSPECTIVES

2023

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15 May 2023 Two scientists in a laboratory

Behind the scenes of innovation

EMBL Grenoble technology teams provide a sneak peek into their latest collaborative project in structural biology services: the complete automation of an integral step in X-ray crystallography.

EMBLetc

2023

16 February 2023

New EU-funded Project: Fragment-Screen

EMBL is one of the partners of this project that aims to accelerate drug discovery and development, bringing in expertise from EMBL Grenoble and EMBL-EBI.

LAB MATTERS SCIENCE & TECHNOLOGY

2023

lab-mattersscience-technology

1 December 2022

Getting closer to stopping toxoplasmosis infection

Recent studies supported by EMBL Grenoble’s expertise in structural biology research and scientific services have identified Altiratinib as a potential drug to stop toxoplasmosis infection and opened up treatment options against malaria.

SCIENCE & TECHNOLOGY

2022

sciencescience-technology

16 November 2022 Photo of Kirill Kovalev adjusting the sample injector at EMBL Hamburg’s P14 beamline.

Molecular solar panels can help scientists control brain cells

Kirill Kovalev, an EMBL Hamburg researcher, is studying the structure of an ancient bacterial molecule to help scientists control brain cell activity

EMBLetc

2022

3 November 2022 View from above of a small room with several tools, cables and pieces of technology. A rectangular box, a robotic arm and a device are highlighted in green.

View from above of a small room with several tools, cables and pieces of technology. A rectangular box, a robotic arm and a device are highlighted in green.

Two in one: combining MASSIF-1 and CrystalDirect

Researchers and engineers have integrated a CrystalDirect harvester into the fully automated beamline MASSIF-1, a unique combination of structural biology technologies that is now open to external academic users.

LAB MATTERS SCIENCE & TECHNOLOGY

2022

lab-mattersscience-technology

10 August 2021 Scientist working on an instrument of the MASSIF-1 beamline

MASSIF-1 beamline in Grenoble supports COVID-19 drug discovery

MASSIF-1, run jointly by EMBL Grenoble and the ESRF, is a beamline for macromolecular crystallography. It is used by the research community to study the 3D structure of proteins, which is important for drug development.

LAB MATTERS SCIENCE & TECHNOLOGY

2021

lab-mattersscience-technology

12 May 2021 The logo of EMBL at PETRA IV is located on the right side of the image. It is a green circle with a curved line in the middle, which symbolises the curve of the synchrotron. The background behind the logo consists of abstract green shapes and multiple 0 and 1 digits.

Shaping the future of structural biology and X-ray imaging at EMBL Hamburg

A workshop run by EMBL Hamburg explored opportunities for structural biology at the future, upgraded PETRA IV synchrotron.

SCIENCE & TECHNOLOGY

2021

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13 April 2021 $Picture showing MD3, the micro-diffractometer developed by the Instrumentation team, installed at one of the EMBL Hamburg's beamline. Credits: Kinga Lubowiecka/EMBL$

Structural biology at EMBL: driving technology development

Florent Cipriani, who recently retired as Head of the Instrumentation Team after a long career at EMBL Grenoble, is one of the pioneers of instrumentation development in this field.

LAB MATTERS SCIENCE & TECHNOLOGY

2021

lab-mattersscience-technology

6 April 2021 A model of Glycine Transporter 1, which is located in the cell membrane. In its lower-middle part, it is bound by its inhibitor, which is a much smaller molecule. At its top, Glycine Transporter 1 is bound by a synthetic mini-antibody, called a sybody.

A model of Glycine Transporter 1, which is located in the cell membrane. In its lower-middle part, it is bound by its inhibitor, which is a much smaller molecule. At its top, Glycine Transporter 1 is bound by a synthetic mini-antibody, called a sybody.

New perspectives for treating psychiatric disorders

Scientists have determined the structure of Glycine Transporter 1. The finding could open new avenues for developing therapeutics for psychiatric disorders

SCIENCE & TECHNOLOGY

2021

sciencescience-technology

30 March 2021 A close-up photo of a shiny droplet of liquid that has been placed into one of the wells of a crystallisation plate.

Droplet beauty

Scientists at EMBL Hamburg use droplets of protein solution to grow protein crystals. By exposing the crystals to X-rays, they are able to determine the protein’s molecular structure.

SCIENCE & TECHNOLOGY

2021

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25 August 2020 Circular beamline building, surrounded by illuminated Grenoble city in the evening and the alps in the background.

Upgraded beamlines at EMBL Grenoble unveiled

The beamlines run jointly by EMBL Grenoble and the ESRF reopen today, unveiling significant upgrades that exploit the brand new fourth generation ESRF synchrotron source.

EMBL ANNOUNCEMENTS

2020

embl-announcementsscience

17 June 2020 $Crystal selection for X-ray diffraction experiments.$

Investigating the structure and mechanisms of coronavirus biomolecules

While global research on coronaviruses has shed light on the function of many SARS-CoV-2 proteins, the role of some crucial components remains unknown. Researchers at EMBL Grenoble will use a range of structural biology methods to try to solve some of the puzzles of the molecular mechanics of…

SCIENCE & TECHNOLOGY

2020

sciencescience-technology

27 May 2020 $Automated sample changer and diffractometer at the ID30B X-ray crystallography beamline at ESRF Grenoble.$

Facilitating COVID-19 structural biology research

EMBL and the European Synchrotron Radiation Facility (ESRF) restart the activities of the Joint Structural Biology Group in Grenoble to support coronavirus-related projects. A new initiative will allow users to be granted access to the High-Throughput Crystallisation (HTX) lab at EMBL and to a…

CONNECTIONS

2020

connectionsscience

5 May 2020 Liquid handling robot transfering protein crystalisation solutions

Responding to health threats posed by coronaviruses

By re-opening the High-Throughput Crystallisation (HTX) lab at EMBL Grenoble, EMBL is supporting structural biology projects to respond to the health threats posed by coronaviruses.

SCIENCE & TECHNOLOGY

2020

sciencescience-technology

28 April 2020 Close-up view of the interior of a protein analytics system

Exploring synthetic antibodies to stop coronavirus

Scientists at EMBL Hamburg and Karolinska Institutet Stockholm aim to find synthetic antibodies – known as nanobodies – that bind a surface protein of the novel SARS-CoV-2 coronavirus. Nanobodies could prevent the virus from entering human cells and causing COVID-19.

SCIENCE & TECHNOLOGY

2020

sciencescience-technology

26 January 2010 This image shows the three-dimensional structure of Death-Associated Protein Kinase (green and yellow) when bound to calmodulin (violet and blue). It was obtained by X-ray crystallography. Image credit: Mathias Wilmanns / EMBL

This image shows the three-dimensional structure of Death-Associated Protein Kinase (green and yellow) when bound to calmodulin (violet and blue). It was obtained by X-ray crystallography. Image credit: Mathias Wilmanns / EMBL

How to shoot the messenger

Cells rely on a range of signalling systems to communicate with each other and to control their own internal workings. Scientists from the European Molecular Biology Laboratory (EMBL) in Hamburg, Germany, have now found a way to hack into a vital communications system, raising the possibility of…

SCIENCE & TECHNOLOGY

2010

sciencescience-technology

8 November 2009

Drought resistance explained

Much as adrenaline coursing through our veins drives our body’s reactions to stress, the plant hormone abscisic acid (ABA) is behind plants’ responses to stressful situations such as drought, but how it does so has been a mystery for years. Scientists at the European Molecular Biology…

SCIENCE & TECHNOLOGY

2009

sciencescience-technology

13 August 2009

Raising the alarm when DNA goes bad

Our genome is constantly under attack from things like UV light and toxins, which can damage or even break DNA strands and ultimately lead to cancer and other diseases. Scientists have known for a long time that when DNA is damaged, a key enzyme sets off a cellular ‘alarm bell’ to alert the…

SCIENCE & TECHNOLOGY

2009

sciencescience-technology

11 January 2006

The giant protein titin helps build muscles

Imagine grabbing two snakes by the tail so that they can’t wriggle off in opposite directions. Scientists at the Hamburg Outstation of the European Molecular Biology Laboratory (EMBL) and collaborators from King’s College in London have now discovered that something similar happens to a…

SCIENCE & TECHNOLOGY

2006

sciencescience-technology

21 December 2005

A key that opens cells to the deadly malaria parasite

Researchers at the International Centre for Genetic Engineering and Biotechnology (ICGEB) in India and a unit of the European Molecular Biology Laboratory (EMBL) in France have made a key discovery about a molecule that helps the malaria parasite infect human cells. India is one of the countries…

SCIENCE & TECHNOLOGY

2005

sciencescience-technology

16 November 2005

New high-throughput crystallization facility at EMBL Hamburg to give boost to structural biology community

Today the European Molecular Biology Laboratory (EMBL) opens a new highthroughput crystallization facility at its Outstation located on the campus of the German Synchrotron Radiation Facility (DESY) in Hamburg, Germany. The facility, made possible by major funds from the German Ministry for Science…

EMBL ANNOUNCEMENTS LAB MATTERS

2005

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