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x-ray crystallography

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27 November 2023 Photo of two people brainstorming at the table covered with several papers and images related to the research project, such as the structure of the molecule, a map with the Solar Lake marked, photo of EMBL Hamburg, photo of Garo Antranikian looking into a microscope, pages of the manuscript, data graphs, and more.

Hamburg collaboration paves the way to cleaner technologies for industry

Science & Technology An interdisciplinary collaboration between Hamburg scientists has yielded new insights into the structure and function of a heat-resistant enzyme from an exotic microbe. In this interview, EMBL Hamburg’s Matthias Wilmanns and TUHH’s Garo Antranikian discuss how their collaboration developed and…

2023

sciencescience-technology

1 November 2023 Sihyun Sung is standing next to experimental equipment for time-resolved serial X-ray crystallography. The light in the room is pink.

We are EMBL: Sihyun Sung on time-resolved structural biology

Lab MattersPeople & Perspectives In this interview, Sihyun Sung, Postdoctoral Fellow at EMBL Hamburg, talks about making molecular movies with time-resolved serial X-ray crystallography, his sources of inspiration, and the value of forging deeper connections with friends and colleagues.

2023

lab-matterspeople-perspectives

15 May 2023 Two scientists in a laboratory

Behind the scenes of innovation

EMBLetc EMBL Grenoble technology teams provide a sneak peek into their latest collaborative project in structural biology services: the complete automation of an integral step in X-ray crystallography.

2023

16 February 2023

New EU-funded Project: Fragment-Screen

Lab MattersScience & Technology EMBL is one of the partners of this project that aims to accelerate drug discovery and development, bringing in expertise from EMBL Grenoble and EMBL-EBI.

2023

lab-mattersscience-technology

1 December 2022

Getting closer to stopping toxoplasmosis infection

Science & Technology Recent studies supported by EMBL Grenoble’s expertise in structural biology research and scientific services have identified Altiratinib as a potential drug to stop toxoplasmosis infection and opened up treatment options against malaria.

2022

sciencescience-technology

3 November 2022 View from above of a small room with several tools, cables and pieces of technology. A rectangular box, a robotic arm and a device are highlighted in green.

Two in one: combining MASSIF-1 and CrystalDirect

Lab MattersScience & Technology Researchers and engineers have integrated a CrystalDirect harvester into the fully automated beamline MASSIF-1, a unique combination of structural biology technologies that is now open to external academic users.

2022

lab-mattersscience-technology

10 August 2021 Scientist working on an instrument of the MASSIF-1 beamline

MASSIF-1 beamline in Grenoble supports COVID-19 drug discovery

Lab MattersScience & Technology MASSIF-1, run jointly by EMBL Grenoble and the ESRF, is a beamline for macromolecular crystallography. It is used by the research community to study the 3D structure of proteins, which is important for drug development.

2021

lab-mattersscience-technology

13 April 2021 Picture showing MD3, the micro-diffractometer developed by the Instrumentation team, installed at one of the EMBL Hamburg's beamline. Credits: Kinga Lubowiecka/EMBL

Structural biology at EMBL: driving technology development

Lab MattersScience & Technology Florent Cipriani, who recently retired as Head of the Instrumentation Team after a long career at EMBL Grenoble, is one of the pioneers of instrumentation development in this field.

2021

lab-mattersscience-technology

6 April 2021 A model of Glycine Transporter 1, which is located in the cell membrane. In its lower-middle part, it is bound by its inhibitor, which is a much smaller molecule. At its top, Glycine Transporter 1 is bound by a synthetic mini-antibody, called a sybody.

New perspectives for treating psychiatric disorders

Science & Technology Scientists have determined the structure of Glycine Transporter 1. The finding could open new avenues for developing therapeutics for psychiatric disorders

2021

sciencescience-technology

30 March 2021 A close-up photo of a shiny droplet of liquid that has been placed into one of the wells of a crystallisation plate.

Droplet beauty

Science & Technology Scientists at EMBL Hamburg use droplets of protein solution to grow protein crystals. By exposing the crystals to X-rays, they are able to determine the protein’s molecular structure.

2021

picture-of-the-weekscience-technology

25 August 2020 Circular beamline building, surrounded by illuminated Grenoble city in the evening and the alps in the background.

Upgraded beamlines at EMBL Grenoble unveiled

EMBL Announcements The beamlines run jointly by EMBL Grenoble and the ESRF reopen today, unveiling significant upgrades that exploit the brand new fourth generation ESRF synchrotron source.

2020

embl-announcementsscience

17 June 2020 Crystal selection for X-ray diffraction experiments.

Investigating the structure and mechanisms of coronavirus biomolecules

Science & Technology While global research on coronaviruses has shed light on the function of many SARS-CoV-2 proteins, the role of some crucial components remains unknown. Researchers at EMBL Grenoble will use a range of structural biology methods to try to solve some of the puzzles of the molecular mechanics of…

2020

sciencescience-technology

27 May 2020 Automated sample changer and diffractometer at the ID30B X-ray crystallography beamline at ESRF Grenoble.

Facilitating COVID-19 structural biology research

Connections EMBL and the European Synchrotron Radiation Facility (ESRF) restart the activities of the Joint Structural Biology Group in Grenoble to support coronavirus-related projects. A new initiative will allow users to be granted access to the High-Throughput Crystallisation (HTX) lab at EMBL and to a…

2020

connectionsscience

5 May 2020 Liquid handling robot transfering protein crystalisation solutions

Responding to health threats posed by coronaviruses

Science & Technology By re-opening the High-Throughput Crystallisation (HTX) lab at EMBL Grenoble, EMBL is supporting structural biology projects to respond to the health threats posed by coronaviruses.

2020

sciencescience-technology

28 April 2020 Close-up view of the interior of a protein analytics system

Exploring synthetic antibodies to stop coronavirus

Science & Technology Scientists at EMBL Hamburg and Karolinska Institutet Stockholm aim to find synthetic antibodies – known as nanobodies – that bind a surface protein of the novel SARS-CoV-2 coronavirus. Nanobodies could prevent the virus from entering human cells and causing COVID-19.

2020

sciencescience-technology

26 January 2010 This image shows the three-dimensional structure of Death-Associated Protein Kinase (green and yellow) when bound to calmodulin (violet and blue). It was obtained by X-ray crystallography. Image credit: Mathias Wilmanns / EMBL

How to shoot the messenger

Cells rely on a range of signalling systems to communicate with each other and to control their own internal workings. Scientists from the European Molecular Biology Laboratory (EMBL) in Hamburg, Germany, have now found a way to hack into a vital communications system, raising the possibility of…

2010

science

8 November 2009

Drought resistance explained

Much as adrenaline coursing through our veins drives our body’s reactions to stress, the plant hormone abscisic acid (ABA) is behind plants’ responses to stressful situations such as drought, but how it does so has been a mystery for years. Scientists at the European Molecular Biology…

2009

science

13 August 2009

Raising the alarm when DNA goes bad

Our genome is constantly under attack from things like UV light and toxins, which can damage or even break DNA strands and ultimately lead to cancer and other diseases. Scientists have known for a long time that when DNA is damaged, a key enzyme sets off a cellular ‘alarm bell’ to alert the…

2009

science

11 January 2006

The giant protein titin helps build muscles

Imagine grabbing two snakes by the tail so that they can’t wriggle off in opposite directions. Scientists at the Hamburg Outstation of the European Molecular Biology Laboratory (EMBL) and collaborators from King’s College in London have now discovered that something similar happens to a…

2006

science

21 December 2005

A key that opens cells to the deadly malaria parasite

Researchers at the International Centre for Genetic Engineering and Biotechnology (ICGEB) in India and a unit of the European Molecular Biology Laboratory (EMBL) in France have made a key discovery about a molecule that helps the malaria parasite infect human cells. India is one of the countries…

2005

science

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