EMBL Grenoble collaborates with the Structural Biology group at the ESRF (European Synchrotron Radiation Facility) in the design, construction, operation and development of synchrotron beamlines for macromolecular crystallography (MX) and small angle X-ray scattering (SAXS).
EMBL Grenoble is also actively involved in the development of advanced scientific instruments and techniques as well as providing expertise for external visitors coming to make measurements.
The Synchrotron Crystallography Team supports access to high brilliance fourth generation synchrotron X-rays on all seven (five MX, one dedicated to time-resolved Serial Synchrotron Crystallography (TR-SSX), and one bioSAXS) of the currently operational EMBL-ESRF Joint Structural Biology Group beamlines:
The team is particularly involved in the operation and development of the ID23-2 microfocus, the new ID29 TR-SSX, the fully automated MASSIF-1 (ID30A-1) with CrystalDirect harvester, and the tunable ID30B MX beamlines as well as the BM29 bioSAXS beamline.
EMBL Grenoble is currently involved in the implementation and development of new data collection protocols using the CrystalDirect harvester on ID30A-1/MASSIF-1, in collaboration with the HTX and Instrumentation teams; dedicated high brilliance TR-SSX experiments for challenging dynamic structural biology projects; X-ray induced hydroxyl radical foot-printing (XFMS) and microfluidic devices for bioSAXS experiments.
Please see Allocation of beamtime for MX for more information on beamtime applications. You are also welcome to contact anyone from the Synchrotron Crystallography Team for additional information.
EMBL Grenoble provides research services including access to its high throughput crystallisation and fragment screening facility (HTX), the fourth-generation synchrotron beamlines for macromolecular crystallography and small-angle scattering at the ESRF, and the PSB-run Titan Krios cryo-electron microscope CM01 at the ESRF.