EMBL Seminars

Connection details
Zoom*: https://embl-org.zoom.us/j/92439170348?pwd=pcdoPcEmYsUbcBenS0SoeM0pF23CPg.1  

(Meeting ID: 924 3917 0348, Password: 717935)

Please note that the talk will be recorded.
*For the FAQ section, as a zoom participant, please use either the chat function (the host will read out your question) or the “raise your hand” function and turn on your microphone.

Abstract
Professionals working in core facilities and scientific services will share their career paths and experiences transitioning from academia into service-oriented scientific roles. Join this webinar to gain insights into daily work in core facilities, the skills required to succeed, key differences compared to PhD or postdoctoral research, and practical advice for those considering a similar career move.

Please register for this zoom webinar: https://embl-org.zoom.us/webinar/register/WN_f2QNItDPSoq0EUxi5qPfdw

Please note that the talk will be recorded.
*For the FAQ section, as a zoom participant, please use either the chat function (the host will read out your question).

Abstract
Super-resolution microscopy has opened new possibilities for visualizing chromatin architecture in situ at nanoscale resolution. Leveraging quantitative super-resolution imaging, we revealed the heterogeneous nature of nucleosome folding and demonstrated that chromatin structure at both nano- and meso-scales is highly plastic, dynamically remodeling in response to chemical and mechanical cues in health and disease. By combining biologically interpretable feature extraction with machine learning, we further showed that cells can be accurately classified into distinct states based solely on their multi-scale chromatin organization, while also identifying the specific chromatin features that drive classification, thus offering mechanistic insight into cell-state regulation.

Communities in the research sector are diverse and form in different ways for a myriad of reasons, yet often researchers find themselves disconnected from one another. Community building is one way to address this disconnect, it is the act of bringing people together under a common goal. In this webinar, Piv Gopalasingam, EMBL-EBI scientific training officer and EMBL Staff Association co-Chair, will introduce the skills you can develop and utilise to build and maintain a community, provide tips and tricks to help assess your group’s needs, and discuss common pitfalls to avoid.

Speakers: Piv Gopalasingam, EMBL-EBI scientific training officer and EMBL Staff Association co-Chair

Connection details
Zoom*: please register at https://embl-org.zoom.us/webinar/register/WN_jCXJMjqiSLWY9rdAPrA-sw 

Please note that the talk will be recorded.
*For the Q&A section, as a zoom participant, please use the Q&A function and the host will read out the questions.

Abstract

Epigenetic components regulate many biological phenomena during development and normal physiology. When dysregulated, epigenetic components can also accompany or drive diseases. One main class of epigenetic components are Polycomb group proteins. Originally, Polycomb proteins were shown to silence gene expression. We found that this function involves the regulation of 3D chromosome folding and we found that Polycomb components can induce the formation of long-distance interactions or chromatin loops that may play instructive roles in gene regulation as well as serve as scaffolding elements that contribute to enhancer-promoter specificity. Perturbation of Polycomb components is involved in human cancer and leads to tumorigenesis in flies. Surprisingly, even upon a transient depletion followed by restoration of the full Polycomb compendium, epithelial cells lose their normal differentiated fate, continue proliferating and establish aggressive tumors, demonstrating that cancer can have a fully epigenetic origin. Similarly, transient perturbation of histone acetylation in mouse ES cells and gastruloids shows that they can record chromatin changes and that this results in cellular memory of the perturbation states. The implication of these data will be discussed.